Same Gender Mammalian Reproduction by Targeted Imprinting Gene Deletion

Published 2025-02-01

In a groundbreaking advancement in regenerative medicine, researchers at the Chinese Academy of Sciences have successfully created mice from two male parents, with some offspring surviving to adulthood. This achievement overcomes previous challenges in same-sex mammalian reproduction by modifying imprinting genes, paving the way for significant progress in stem cell and regenerative medicine research. The study was published as "Generation of Bi-paternal Mice that Can Develop to Adulthood through Targeted Imprinting Gene Deletion," published in Cell Stem Cell on January 28, 2025